Genetic Risk Factors Found For Most Common Brain Tumors

News — By on July 6, 2009 at 6:29 am

For the first time, researchers have identified genetic variants commonly found in the population that can increase an individual’s risk of developing glioma, the most prevalent brain tumor. The findings are published today in the journal Nature Genetics.

Scientists at The Institute of Cancer Research in the UK, The University of Texas M.D. Anderson Cancer Center in the US and elsewhere in Europe collaboratively studied the DNA sequences of thousands of people and found five genetic factors that were more common among people who had glioma.

“This is a major discovery,” commented article author and lead researcher Professor Richard Houlston, from the ICR and funded by the Wellcome Trust and Cancer Research UK. “We’ve found the first real evidence that variations in the genes which many people carry can increase their risk of this deadly disease, glioma.”

People who have a relative diagnosed with brain cancer are twice as likely to be diagnosed with a brain tumor. Researchers have previously identified a few rare genetic disorders that increase the risk of brain tumor – but these can only explain a small part of the inherited risk.

Genetic research over recent years has increasingly revealed that most cancers are not triggered by one or two genetic mutations, but instead the involvement of many genetic factors that each slightly increase the risk of cancer.

The scientists theorized that most of the genetic risks of brain tumors were likely due to inheriting several low-risk variants.

Please read the complete article and let us know what you think below.

Tags: , ,

Leave a Reply


Leave a Trackback